GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person

Abstract

Circadian rhythms are a nearly universal feature of living organisms and affect almost every biological process. Our innate preference for mornings or evenings is determined by the phase of our circadian rhythms. We conduct a genome-wide association analysis of self-reported morningness, followed by analyses of biological pathways and related phenotypes. We identify 15 significantly associated loci, including seven near established circadian genes (rs12736689 near RGS16, P=7.0 × 10-18; rs9479402 near VIP, P=3.9 × 10-11; rs55694368 near PER2, P=2.6 × 10-9; rs35833281 near HCRTR2, P=3.7 × 10-9; rs11545787 near RASD1, P=1.4 × 10-8; rs11121022 near PER3, P=2.0 × 10-8; rs9565309 near FBXL3, P=3.5 × 10-8. Circadian and phototransduction pathways are enriched in our results. Morningness is associated with insomnia and other sleep phenotypes; and is associated with body mass index and depression but we did not find evidence for a causal relationship in our Mendelian randomization analysis. Our findings reinforce current understanding of circadian biology and will guide future studies.