Synthesis, chemical and biological investigations of new Ru(III) and Se(IV) complexes containing 1,3,5-triazine chelating derivatives

Abstract

A series of vital complexes of [Se (L n ) (Cl) x ]·yCl (where n = L 1 , L 2 , L 3 and L 4 ; x = 1, 2, or 3 and y = 1, 2, or 3) and [Ru (L n ) (Cl) x (H 2 O) y ]zCl (where x = 2 or 3; y = 0,1 or 2 and z = 0 or 1) have been synthesized from the chemical reactions between ruthenium (III) or selenium (IV) salts and tri-substituted s-triazine derivatives (L 1 = N 2 -(4-chlorophenyl)-N 4 ,N 6 -di (pyrimidin-2-yl)-1,3,5-triazine-2,4,6-triamine; L 2 = N 2 -(4-chlorophenyl)-N 4 - (pyrimidin-2-yl)- N 6 - (thiazol-2-yl)-1,3,5-triazine-2,4,6-triamine; L 3 = 6-chloro-N 2 -(pyrimidin-2-yl)-N 4 -(1H-1,2,4-triazol-3-yl)-1,3,5-triazine-2,4-diamine and L 4 = 6-chloro-N 2 -(4-chlorophenyl)-N 4 -(pyrimidin-2-yl)-1,3,5-triazine-2,4-diamine). The structural was investigated using of elemental analyses, molar conductance, IR, UV–Vis, magnetic susceptibility, 1 H, 13 C NMR spectra and thermal analyses. The surface morphology behaviors of selenium (IV) and ruthenium (III) complexes were studied based on scanning and transmittance electron microscopes. The crystalline nature of s-triazine complexes have been investigated using X-ray powder diffraction spectra. Spectral results were concluded that the ligand acts as a neutral bidentate for (L 1 and L 4 ) and tridentate for (L 2 and L 3 ), and coordinates through the nitrogen atom of triazine ring and nitrogen atoms of (pyrimidine, thiazole, and triazole) rings towards metal ion. The cytotoxic IC 50 results of the free L n ligands and its selenium (IV) complexes in vitro against the human colon and lung cancer cell lines introduced a promising efficiency.