Effect of corn silk powder extracts using in vivo to lipid profile and liver fat

Abstract

This study aimed to determine the effect of corn silk powder extracts using in vivo to lipid profile and liver fat (a liver weight and adipose fat). The used experimental animals were 30 Sprague Dawley mice with 200-250 g mice weight divided into 6 groups. Each group of 5 mice was randomly determined, then the mice were caged individually. At the time of intervention for 21 days, group I received standard food, group II got hypercholesterolemia induction, group III received high-fat food induction and simvastatin drug, group IV induced hypercholesterolemia and corn silk extract dose 2.25ml, group V induced hypercholesterolemia and extract corn silk dose 4.5 ml, and group VI got hypercholesterolemia induction of corn silk extract dose 6.75 ml. The provision of corn silk extracts is based on recommendations for consumption of vegetables per day in humans from the Food and Drug Administration (FDA) which is 30-40 g/day. Corn silk extracts were given as much as 125 ml; 250 ml; and 375 ml. The dose was then converted to mice (0.018) to obtain 2.25 ml; 4.5 ml; and 6.75 ml. Corn silk powder extracts significantly affected (p<0.05) on lipid profile and liver fat (a liver weight and adipose fat). The best corn silk powder extract was at a dose of 2.25 ml with lipid profile (total cholesterol of 24.4% from 120.29±2.23 ml/dl to 90.87 ±2.01 ml/dl, HDL cholesterol of 30.35% from 56.60 ±2.81 ml/dl to 81.26±1.88 ml/dl, LDL cholesterol of 53.84% from 57.47±0.82 ml/dl to 26.53±0.77 ml/dl, triglycerides of 29.14% from 98.15±1.92 ml/dl to 69.54±6.78 ml/dl), and liver fat content in P3 treatment dose 6.75 ml with a liver weight of 7.09 g and adipose fat of 6.99 g.