Advances in the clinical application of Raman spectroscopy in breast cancer

Abstract

Recently, Raman spectroscopy has made phased progress in clinical research of breast cancer. Raman spectroscopy is a nondestructive optical analysis technology that can quickly provide biochemical molecular specific information of samples. The analysis of Raman spectral characteristics at different stages of clinical activity in breast cancer patients is helpful to formulate individualized diagnosis and treatment plans, improve surgical results, adjust treatment strategies, and promote prognosis. Due to the development of optical technology and the diversity of clinical research needs, derivative Raman techniques based on Raman effect have emerged, such as surface-enhanced Raman spectroscopy, resonance Raman spectroscopy, spatial shifted Raman spectroscopy and coherent Raman scattering spectroscopy. In this paper, the research progress of Raman spectroscopy and its derivative techniques in the diagnosis and treatment of breast cancer in recent years is reviewed. The diagnostic value of different Raman techniques in different levels of breast cancer cells, body fluids and breast tissue and microcalcification molecules is evaluated. In addition, the application status and prospects of Raman spectroscopy and its derivative techniques in breast cancer surgery, chemotherapy and radiotherapy are analyzed and discussed.