Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk

Abstract

Cancer predisposition syndromes, particularly neurofibromatosis type 1 (NF1), provide unique vantage points from which to examine the co-contributions of molecular, cellular, and tissue processes to tumor biology. Polymorphisms in adenylate cyclase 8 affect brain tumor risk in NF1 in a sex-specific fashion, illuminating novel interdependencies in brain tumorigenesis.