Assessment of anti-inflammatory of stem extract of Musa balbisiana in wound healing on rats (Rattus norvegicus)

Abstract

Background: Balbisiana is a plant that contains flavonoids, which are antioxidants with high anti-inflammatory activity. This antioxidant activity can help the wound-healing process. Purpose: To determine the anti-inflammatory effect of balbisiana extract to help wound healing. Method: The study used 15 rats, which were divided into five groups: a positive control group, a negative control group, a 10% balbisiana extract group, a 20% balbisiana extract group, and a 40% balbisiana extract group. Statistical analysis was performed using the Shapiro-Wilk test to test the normality of the distribution of continuous quantitative data. Levene's test was then used to assess the statistical homogeneity of variance between groups. Welch's One-Way ANOVA was used to analyze the data. Post-hoc analysis was performed using the Games-Howell test. Results: The results of the study showed that balbisiana extract had significant anti-inflammatory activity, especially at a concentration of 40%. This was demonstrated by the results of the study, which showed that rats treated with 40% balbisiana extract had significantly improved wound healing compared to the control groups. Conclusion: This study shows that balbisiana extract has anti-inflammatory activity in helping the wound healing process.