A facile route for the preparation of N-phenyl tetrahydroquinolines and tetrahydroisoquinolines

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Abstract

A convenient N-arylation of tetrahydroquinoline and tetrahydroisoquinoline is described using electron-poor, electron-neutral, or electron-rich arylhalide derivatives and palladium(II)-BINAP as a catalyst.

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Meneyrol, J., Helissey, P., Tratrat, C., Giorgi-Renault, S., & Husson, H. P. (2001). A facile route for the preparation of N-phenyl tetrahydroquinolines and tetrahydroisoquinolines. Synthetic Communications, 31(7), 987–992. https://doi.org/10.1081/SCC-100103526

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