A 16-week supplementation with a polyphenol-rich supplement, Sinetrol® Xpur, aids in fat loss of overweight and obese volunteers: a randomised, double-blind, parallel trial

Abstract

This clinical trial evaluates the effect of a polyphenol-rich ingredient on body composition management in 77 overweight and obese, but otherwise healthy, men and women for 16 weeks and 4 weeks of follow-up. Subjects received a placebo or a polyphenol-rich ingredient (Sinetrol® Xpur) at a dose of 900 mg/day. Participants followed a normocaloric diet and continued with their usual physical activity during the study. Total fat% significantly decreased by 1.98% (SD 3.5) in the polyphenol-supplemented group after 16 weeks compared to the placebo group. This decrease was accompanied by a trend (p = 0.06) towards an increase in lean mass compared to the placebo group and an increase in Resting energy expenditure (p = 0.02) within the polyphenol-supplemented group. All the safety parameters were within normal ranges and no adverse effect was noticed. Overall, this 16-week supplement intake might have contributed to body composition management and may help prevent the regain of fat during the 4-week follow-up. Trial registration number: NCT04149158.