Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing

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Abstract

Flea-borne (murine) typhus is caused by Rickettsia typhi. Infection in pregnant women can lead to adverse outcomes when diagnosis and treatment is delayed. We describe how next-generation sequencing (NGS) using the Karius® test was used to rapidly diagnose murine typhus in two pregnant women admitted to a large tertiary care center in Houston, Texas, when all initial testing was nondiagnostic.

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Stafford, I. A., Centeno, F. H., Al Mohajer, M., Parkerson, G., Woc-Colburn, L., Burgos-Lee, A. J., … Muldrew, K. (2020). Successful Detection of Unrecognized Rickettsia typhi in Pregnancy Using Cell-Free Next-Generation Sequencing. Case Reports in Obstetrics and Gynecology, 2020. https://doi.org/10.1155/2020/6767351

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