In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of L-tryptophan and L-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.
CITATION STYLE
Wu, D. L., Li, H. J., Smith, D. R., Jaratsittisin, J., Xia-Ke-Er, X. F. K. T., Ma, W. Z., … Lan, W. J. (2018). Polyketides and alkaloids from the marine-derived fungus Dichotomomyces cejpii F31-1 and the antiviral activity of scequinadoline A against dengue virus. Marine Drugs, 16(7). https://doi.org/10.3390/md16070229
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