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Sodium 4-phenylbutylate protects against myocardial ischemia-reperfusion injury by reducing unfolded protein response-mediated apoptosis in mice

  • Okajima M
  • Takamura M
  • Usui S
  • et al.
Critical Care (2010) 14(Suppl 1) P2
DOI: 10.1186/cc8234
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Abstract

Unfolded protein response (UPR)-mediated apoptosis plays a pivotal role in ischemia-reperfusion injury. Sodium 4-phenylbutyrate (PBA) has been reported to act as a chemical chaperone inhibiting UPR-mediated apoptosis triggered by ischemia in various organs other than the heart. Therefore we investigated whether PBA reduces UPR-mediated apoptosis and protects against myocardial ischemia-reperfusion injury in mice.

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APA

Okajima, M., Takamura, M., Usui, S., Taniguchi, T., & Kaneko, S. (2010). Sodium 4-phenylbutylate protects against myocardial ischemia-reperfusion injury by reducing unfolded protein response-mediated apoptosis in mice. Critical Care, 14(Suppl 1), P2. https://doi.org/10.1186/cc8234

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