Utilization of ultrasonic as an approach of green chemistry for synthesis of hydrazones and bishydrazones as potential antimicrobial agents

Abstract

Hydrazides 3,4, Hydrazones 6a-c, bishydrazones 8a,b, N-hydroxy-N'- arylpropanehydrazonamide 9a,b and 1-(piperidin-1-yl)-N2-arylamidrazones 10a,b were prepared under ultrasonic waves as an approach for green chemistry. a notable good yield and short reaction time were afforded under ultrasonic waves.The structures of compounds were confirmed in terms of spectroscopic and elemental analyses. The invitro antimicrobial activity of the prepared compounds were evaluated. most of compounds exhibited an excellent growth inhibition such as compounds 2, 3 and 8b against gram positive bacteria, while 2, 3, 8b, 9a, 10a and 10b against gram negative bacteria. all of tested compounds have excellent or good antifungal activity except 3.