Translationally controlled tumor protein is a novel biological target for neurofibromatosis type 1-associated tumors

Abstract

Background: Loss of NF1 gene function predisposes individuals to develop NF1-associated tumors, for which there are no known biomarkers/therapeutic targets. Results: TCTP was up-regulated in NF1-associated tumors and enhanced their growth via its positive feedback to the mTOR signaling, which was inhibited by artesunate/rapamycin. Conclusion: TCTP is a novel target functionally implicated in NF1 tumorigenesis. Significance: TCTP could serve as a biomarker/therapeutic target for NF1-associated tumors.