Phytochemical Constituents and Activities of Morinda citrifolia L.

Abstract

Both artificial and naturally occurring antioxidants have been reported to play major roles in protecting membranes and tissues from free radical and xenobiotic-induced oxidative damage (Burton, 1989; Carini et al., 1990). Most living organisms harbour both enzymatic and non-enzymatic systems that protect them against excessive reactive oxygen species. However, various external factors (smoke, diet, alcohol and some drugs) and aging decrease the efficiency of these protective systems, thereby disrupting the redox equilibrium that is established under healthy conditions. Thus, antioxidants that scavenge reactive oxygen species may be of great value in preventing the onset and propagation of oxidative diseases (Willet, 1994). Recently, more attention has been paid to the role of natural antioxidants, mainly phenolic compounds, which may have higher antioxidant activity than do conventional antioxidants, such as vitamins C, E and β-carotene (Vinson et al., 1995). The anti-oxidative effects of natural phenolic compounds, in pure form or in extracts from various plant sources (vegetables, fruits and medicinal plants), have been studied in vitro using a variety of model systems (Meyer et al., 1998; Pietta et al., 1998; Yen & Hsieh, 1998). Therefore, antioxidants, which can neutralize free radicals, may be of central importance in the prevention of carcinogenicity, cardiovascular disease and neurodegenerative changes associated with aging (Halliwell, 1994; Yu, 1994). Epidemiological studies have shown that the consumption of vegetables and fruits can protect humans against oxidative damage by inhibiting and/or quenching free radicals and reactive