Antibacterial cobalt (II), copper (II), nickel (II) and zinc (II) complexes of mercaptothiadiazole - Derived furanyl, thienyl, pyrrolyl, salicylyl and pyridinyl Schiff bases

Abstract

A series of Co (II), Cu (II), Ni (II) and Zn (II) complexes of mercaptothiadiazole - derived furanyl, thienyl, pyrrorlyl, salicylyl and pyridinyl Schiff bases were synthesized, characterized and screened for their in vitro antibacterial activity against four Gram-negative, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Shigella flexneri, and two Gram-positive; Bacillus subtilis and Staphylococcus aureous bacterial strains. The results of these studies show the metal complexes to be more antibacterial as compared to the prepared un-complexed Schiff bases. © 2006 Taylor & Francis.