Vitamin B12 deficiency: Cognitive impairment and neuroimaging correlates

Abstract

Vitamin B12 deficiency has been associated with various neuropsychiatric symptoms, and to be a reversible cause of dementia. As the negative impact of low vitamin B12 status on cognition can range from subclinical neuronal metabolic derangement to an overt debilitating state in line with permanent brain structural changes, prompt recognition of vitamin B12 deficiency is of paramount clinical importance as it is a treatable condition. Several studies have investigated the pathogenesis of vitamin B12 deficiency.