Intermittent active motion versus immobilization in the treatment of Staphylococcus aureus - Induced arthritis in a rabbit model

Abstract

Purpose: This study has evaluated the effects of immobilization versus intermittent active motion on cartilage and on antibiotic efficacy in a rabbit septic arthritis model. Methods: Rabbits were infected and assigned to one of four groups: group 1, no treatment without immobilization (allowing intermittent active motion); group 2, cast; group 3, oxacillin without immobilization; group 4, oxacillin and cast. Animals were sacrificed 21 days later. Bacterial counts and lateral radiograms were performed. A radiological score was calculated. Results: Immobilization had no effect on oxacillin efficacy and a deleterious effect on the radiological score. Conclusion: Intermittent active motion has allowed a better cartilage healing during the treatment of septic arthritis. © EPOS 2008.