Isolation and structure of hematoside-type ganglioside from the starfish linckia laevigata

Abstract

A hematoside-type ganglioside, LLG-1 (1), has been obtained from the polar lipid fraction of the chloro- form/methanol extract of the starfish Linckia laevigata. The structure of the ganglioside has been determined on the basis of chemical and spectroscopic evidence as 1-0-[N-glycolyl-α-D-neuraminosyl- (2→3)-β-D-galactopyra-nosyl-(1→4)-β-D-glucopyranosyl] -ceramide. The ceramide moiety was composed of heterogeneous 2-hydroxy fatty acid and phytosphingosine units. This is the first report on the isolation and structure elucidation of naked hematoside-type ganglioside from echinoderms. © 2009 Pharmaceutical Society of Japan.