Non-Enzymatic Electrochemical Sensing of Glucose with Silver Nanoparticles Supported on Poly(3-aminobenzoic acid)

Abstract

This study explores the development of a non-enzymatic electrochemical glucose sensor based on poly(3-aminobenzoic acid) (P3ABA) combined with silver nanoparticles (AgNPs). Incorporating AgNPs into the P3ABA matrix enhances the sensor’s electrocatalytic properties, leading to a system with greater stability. Cyclic voltammetry and chronoamperometry were employed to evaluate the sensor’s performance, demonstrating a sensitivity of 50.71 µA mM−1 cm−2 and a limit of detection (LOD) of 0.2 µM. The sensor exhibited a linear response over a broad concentration range (1 to 16 mM), with a coefficient of determination (R2) of 0.998, indicating good reproducibility and precision. These results highlight the potential of the P3ABA/AgNP composite for glucose sensing applications, offering an extended linear range, allowing for the quantification of glucose concentrations from very low to significantly high levels, covering both physiological and pathological conditions.