Antithyroid activity of n-phthalyl glutamic acid imide (k 17)

Abstract

The effects of N-phthalyl glutamic acid imide (K 17) on thyroid uptake of radioactive iodine have been assessed in nine euthyroid patients. From the results obtained it appears that N-phthalyl glutamic acid imide has a mild but definite antithyroid activity when given in doses of 200 mg. or more. At present the mode of its action is unknown. In the meantime, therefore, it would seem unjustifiable to use the drug for long-term sedative or hypnotic therapy, pending the results of a more detailed study of its long-term effects in a larger series of patients, and notably those suffering from mild or moderately severe hyperthyroidism. © 1958, British Medical Journal Publishing Group. All rights reserved.