Frontiers in Clinical Drug Research CNS aND Neurological Disorders

Abstract

THE ROLE OF DEXMEDETOMIDINE ON NEUROPROTECTION. Intro; CONTENTS; PREFACE; List of Contributors; Depression, Insomnia and Atypical Antidepressants; Laura Betti1,*, Lionella Palego2 and Gino Giannaccini1; INTRODUCTION; Neurobiology of Sleep; Mammalian Sleep: Evolution and Architecture; Sleep and Mood; Sleep and Ageing; Subjective Evaluations of Sleep; INSOMNIA IN DEPRESSION; Major Depression; Seasonal Depression, Atypical Depression; Depression with Anxiety; Bipolar Disorder; TREATMENT OF INSOMNIA; ANTIDEPRESSANTS AND SLEEP; First Generation Antidepressants; Second Generation Antidepressants, SSRIs and SNRIs. Selective Noradrenalin Reuptake Inhibitors (NARIs)Atypical Antidepressants; Trazodone and Melatonin; CONCLUSION; CONSENT FOR PUBLICATION; CONFLICT OF INTEREST; ACKNOWLEDGMENTS; REFERENCES; Combination Therapy of Hypothermia for Hypoxic Encephalopathy in Neonates; Renjith Kalikkot Thekkeveedu, Abhay Bhatt, Sumana Ramarao, Zhengwei Cai and Yi Pang*; INTRODUCTION: PERINATAL BRAIN INJURY AND TREATMENT; HYPOTHERMIA TREATMENT; The Evolvement of Hypothermia as a Neuroprotective Strategy; Mechanisms Underlying Neuroprotective Effects of TTM; Clinical Trials of TTM on HIE: Success and Limitation. Clinical Trials that Reported Short-term EvaluationClinical Trials, Long-term Outcomes; Safety and Complications; COMBINED THERAPY OF TTM WITH OTHER NEUROPROTECTANTS; Multiple Mechanisms: Erythropoietin (EPO); Anti-oxidant; Anesthetic Gas Xenon; Trophic Factors; Anticonvulsants; Stem Cell Transfusion; CONCLUDING REMARKS; CONSENT FOR PUBLICATION; CONFLICT OF INTEREST; ACKNOWLEDGMENT; ABBREVIATIONS; REFERENCES; Development of A "Theranostic Nano-Bullet" for Tinnitus: A Systems Neuroscience Approach for Receptor Targeting, Molecular Imaging, and Drug Delivery. Anthony T. Cacace*, Aaron K. Apawu, Stephanie M. Curley, James Castracane, Magnus Bergkvist, Angela R. Dixon and Avril Genene HoltINTRODUCTION; Multifunctional Carriers: Detection, Targeting, and Treatment; Molecular Profiling and Biomarkers Associated with Tinnitus: Gene Expression Experiments to Target Pathologic Neural Activity; Attenuating Tinnitus based on Manganese Enhanced Magnetic Resonance Imaging (MEMRI) and Molecular Identification of Protein Targets; BACKGROUND; Models and Theories of Tinnitus; Roadmap to a Cure; The Urgent Need for Development of Pharmacological Treatments. Issues Related to BBB Transport with NPsIn-vitro and In Vivo Experiments; In-Vivo Transport of Nanocarriers Across Brain Barriers; SUMMARY; CONCLUDING REMARKS; CONSENT FOR PUBLICATION; CONFLICT OF INTEREST; ACKNOWLEDGMENT; ABBREVATIONS; REFERENCES; Dexmedetomidine: From Basic Science to Clinical Application of Brain Protection; Zhaosheng Jin1,#, Ka Chun Suen1,#, Azeem Alam1,#, Zac Hana1,#, Dongxin Wang2 and Daqing Ma1,*; INTRODUCTION; PHARMACOLOGY OF DEXMEDETOMIDINE; α2-adrenoreceptors; α2-subreceptors; Distribution; Pharmacokinetics; Distribution; Metabolism; Elimination; Considerations.