Two-directional synthesis as a tool for diversityoriented synthesis: Synthesis of alkaloid scaffolds

Abstract

Two-directional synthesis represents an ideal strategy for the rapid elaboration of simple starting materials and their subsequent transformation into complex molecular architectures. As such, it is becoming recognised as an enabling technology for diversityoriented synthesis. Herein, we provide a thorough account of our work combining two-directional synthesis with diversity-oriented synthesis, with particular reference to the synthesis of polycyclic alkaloid scaffolds. © 2012 Ma et al; licensee Beilstein-Institut.