Journal ArticleOPEN ACCESS

Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy

  • Assadi M
  • Wang D
  • Velazquez-Rodriquez Y
  • et al.
Journal of Central Nervous System Disease (2013) 5 JCNSD.S11861
DOI: 10.4137/jcnsd.s11861
N/ACitations
Citations of this article
11Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Metachromatic leukodystrophy (MLD) is characterized by the accumulation of sulfatide sphingolipids in the brain and peripheral nerves. We report metabolite alterations recorded using multi-voxel proton spectroscopy of the brain in four children with MLD. The data revealed elevated myoinositol/creatine and lactate/creatine ratios as well as decreased N-acetyl aspartate/creatine ratios. We propose that elevation in myoinositol and lactate are caused by astrocytic gliosis and may be used as biomarkers for disease progression in MLD.

Cite

CITATION STYLE

APA

Assadi, M., Wang, D.-J., Velazquez-Rodriquez, Y., & Leone, P. (2013). Multi-Voxel 1H-MRS in Metachromatic Leukodystrophy. Journal of Central Nervous System Disease, 5, JCNSD.S11861. https://doi.org/10.4137/jcnsd.s11861

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free