Perfusion System Controller Strategies during an ECMO Support

Abstract

In this work modelling and control of Perfusion system is presented. The Perfusion system simultaneously controls the partial pressures during Extra Corporeal Membrane Oxygenation (ECMO) support. The main Problem in ECMO system is exchange of Blood Gases in the Artificial Lung (Oxygenator).It is a highly Nonlinear Process comprising time-varying parameters, and varying time delays, it is currently being controlled manually by trained Perfusionist. The new control strategy implemented here has a feedback linearization routine with time-delay compensation for the Partial pressuresof Oxygen and Carbon dioxide. The controllers were tuned robustly and tested in simulations with a detailed artificial Lung (Oxygenator) model in Cardiopulmonary bypass conditions. This Automatic control strategy is proposed to improve the patient's safety by fast control reference tracking and good disturbance rejection under varying conditions. KEYWORDS Cardio Pulmonary Bypass (CPB), Blood Gas Analyser (BGA), Extra Corporeal Membrane Oxygenator (ECMO)