Frequencies of peripheral blood myeloid cells in healthy Kenyan children with α+ thalassemia and the sickle cell trait

10Citations
Citations of this article
44Readers
Mendeley users who have this article in their library.

Abstract

The high frequencies of both α+ thalassemia and the sickle cell trait (hemoglobin AS [HbAS]) found in many tropical populations are thought to reflect selection pressure from Plasmodium falciparum malaria. For HbAS, but not for α+ thalassemia, protection appears to be mediated by the enhanced phagocytic clearance of ring-infected erythrocytes. We have investigated the genotype-specific distributions of peripheral blood leukocyte populations in two groups of children living on the coast of Kenya: a group of healthy P. falciparum parasite-negative children sampled at cross-sectional survey during a period of low malaria transmission, and a group of children attending the hospital with acute malaria. We report distinctive distributions of peripheral blood myeloid dendritic cells and monocytes in children with α+ thalassemia and HbAS during healthy periods and disease, and suggest ways in which these might relate to the mechanisms of protection afforded by these conditions. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.

Cite

CITATION STYLE

APA

Urban, B. C., Shafi, M. J., Cordery, D. V., Macharia, A., Lowe, B., Marsh, K., & Williams, T. N. (2006). Frequencies of peripheral blood myeloid cells in healthy Kenyan children with α+ thalassemia and the sickle cell trait. American Journal of Tropical Medicine and Hygiene, 74(4), 578–584. https://doi.org/10.4269/ajtmh.2006.74.578

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free