A systematic review of therapeutic proteins as a promising approach to treat various diseases

Abstract

Proteins if said as ‘magic molecules’ will not prove false because of a varied play it can deal with in view of health sector. In the past couple of decades, therapeutic proteins have gained significance as therapy for a wide range of diseases like cancer, cardiovascular, diabetes and some other diseases. Moreover, recently USFDA protein therapeutic products are also playing an important role in this concern. Whereas therapeutic application of whey protein is rapidly on its way to be proved helpful. The thing of concern to use of these therapeutic proteins for the treatment of various diseases is a proper and rational formulation of protein-based therapeutics. Advancements in the field of biotechnology have increased and facilitated the production of therapeutically significant proteins to combat various potentially fatal diseases. However, there are still a few factors that hinder the efficient use of these valuable therapeutics. For instance, the oral route of administration faces proteolysis and/or hydrolysis in the GIT, whereas some drugs go through the hepatic first pass effect or show poor distribution. Therefore, a better insight into the routes of administration and the drug absorption mechanisms (paracellular, transcellular, and carrier mediated) is essential. This review has explained all the possible factors that are linked with the basis of therapeutic proteins, including their introduction, classification, their importance in the healthcare system, and possible challenges that are currently being faced by scientists during the development of protein-based therapeutics.