Mechanical stability and fibrinolytic resistance of clots containing fibrin, DNA, and histones

Abstract

Background: Neutrophil extracellular traps (NETs) composed of DNA and proteins form a scaffold in thrombi, supplementing the fibrin matrix. Results: DNA and histones modify the structure of fibrin and render it resistant to mechanical and enzymatic destruction. Conclusion: NET components are essential factors in thrombus stability. Significance: Therapeutic strategies could be optimized to enhance fibrinolysis in clots containing DNA and histones. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.