New proteasome inhibitors in the treatment of multiple myeloma

3Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.

Abstract

The treatment of patients with relapsed and/or refractory multiple myeloma has improved considerably in the last 15 years, after the introduction of proteasome inhibitors and immunomodulatory drugs. The first clinical trials with new proteasome inhibitors have produced exciting results, particularly those comparing triplet regimens with standard doublet regimens, with a gain in progression-free survival accompanied by an acceptable safety profile and either similar or better health-related quality of life. New proteasome inhibitors hold the potential to fill unmet needs in multiple myeloma management regarding improvement of clinical outcomes, including delayed progression of disease in high-risk patients. This review summarizes the main pharmacological properties and clinical outcomes of these agents, and discusses their potential to change the whole multiple myeloma therapeutic landscape.

Cite

CITATION STYLE

APA

Hungria, V. T. de M., Crusoé, E. de Q., Bittencourt, R. I., Maiolino, A., Magalhães, R. J. P., Sobrinho, J. do N., … Tanaka, P. Y. (2019, January 1). New proteasome inhibitors in the treatment of multiple myeloma. Hematology, Transfusion and Cell Therapy. Elsevier Editora Ltda. https://doi.org/10.1016/j.htct.2018.07.003

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free