Association between liver fluke infection and hepatobiliary pathological changes: A systematic review and meta-analysis

Abstract

Objective: to Provide Info. about the Role of Liver Fluke Infect. As A Risk Factor for Hepatobiliary Pathol. Changes and Promote Awareness among the People Living in Endemic Areas, A Syst. Rev. and Meta-Anal. Based on Publ. Studs. Was Conducted to Examine the Assoc. between Liver Fluke Infect. and Hepatobiliary Pathol. Changes. Methods: Relevant Original Lit. Was Searched Inmultiple Lit. Databases, Including PubMed, Cochrane, Clin. Evidence, Trip Database, Clin. Trials, Current Controlled Trials, Web of Sci., the China Natl. Knowledge Infrastruct. Database, and TheWanfang Acad. Jnl. Full-text Database. Studs. Were Selected Based on Strict Screening with Inclusion and Exclusion Criteria. Tests of Heterogeneity, Sensitivity and Publication Bias Were Performed with the Rev. Manager Software, Version 5.3, and Meta-regression Analyses Were Performed with the Stata Software, Version 11.0 . Pooled Risk Ratios and Odds Ratios with Their 95%confidence Intervals Were Calculated and Used to Evaluate the Risk of Hepatobiliary Pathol. Changes Resulting from Liver Fluke Infect.. Lin. Trend Analyses Were Conducted to Determine the Dose-response Relationship Using IBM SPSS Stat. 20.0. Result: A Total of 36 Studs. Were Included in the Meta-Anal.. Significant Associations Were Found between Liver Fluke Infect. and Cholangitis or Cholecystitis , Cholelithiasis , Hepatocellular Carcinoma and Cholangiocarcinoma . in Addition, Heavier Infect. Was Significantly Assoc. with Higher Incidence of Hepatobiliary Pathol. Changes . However, Cirrhosis Was Not Significantly Assoc. with Liver Fluke Infect. . the Stat. Heterogeneitywas Significant, No Significant Difference Was Observed in the Sensitivity Anal., and No Publication Bias Was Found. Conclusion: the Meta-Anal. Found That Liver Fluke Infect. Was Significantly Assoc. with Cholangitis, Cholecystitis, Cholelithiasis, Hepatocellular Carcinoma and Cholangiocarcinoma and That More Severe Infect. Was Assoc. with Higher Incidence. However, the Assoc. between Liver Fluke Infect. and Cirrhosis Was Not Significant.