Abstract
Background: PDGF is a potent chemoattractant for cells. Results: The PDGF-induced extracellular matrix component Cyr61 bridges the intracellular PDGF-ERK and JNK signaling pathways with integrin/FAK signaling, leading to cell migration. Conclusion: Cyr61 is a key mediator of PDGF-induced cell migration via the Cyr61-integrin-FAK pathway. Significance: Extracellular Cyr61 convergence with growth factor and integrin/FAK signaling is a new cell migration concept.
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CITATION STYLE
Zhang, F., Hao, F., An, D., Zeng, L., Wang, Y., Xu, X., & Cui, M. Z. (2015). The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration. Journal of Biological Chemistry, 290(13), 8232–8242. https://doi.org/10.1074/jbc.M114.623074
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