Evaluation of Topical Pomegranate Extracts in Management of Oral Lichen Planus: A randomized clinical trial

Abstract

Background: The current study aimed to evaluate the effect of using topical pomegranate extracts gel versus topical steroid gel as a control in management of atrophic oral lichen planus (OLP). Materials and methods: Forty-two patients presenting clinically with atrophic OLP were involved in the study. They were randomly divided into three equivalent groups to be managed with topical corticosteroid gel as control (Group 1, Group C), topical pomegranate seed extract gel (Group 2, Group S) and topical pomegranate peel extract gel (Group 3, Group P). Assessment of pain, sign scores and oral health impact profile- 14 (OHIP- 14) were carried out in each group before and after the used management protocols. Results: The results showed a significant decrease in sign; pain scores and OHIP-14 values which were recorded in group S and group P. Conclusion: Provided data in this contemplate using topical pomegranate seeds and peel extracts gel offer a new promising natural, safe and effective management of OLP.