Iron-Catalyzed, Light-Driven Decarboxylative Oxygenation

Abstract

An iron-catalyzed, visible light-driven, dioxygen mediated decarboxylative oxygenation of carboxylic acids is disclosed. The catalytic system based on naturally existing Mohr salt and simple di(2-picolyl)amine ligand is readily available and inexpensive. The applicability of the method was demonstrated through the efficient and selective synthesis of a range of ketones, aldehydes and amides including drug derivatives. Based on experimental investigations, a hypothetical mechanism was proposed.