Synthesis of some new substituted 2-mercaptoquinazoline analogs as potential antimicrobial agents

Abstract

A new series of substituted 2-mercapto-3-(4-chlorophenyl)-6-iodo-3H- quinazolin-4-ones was prepared and screened for antimicrobial activity. Compounds 11, 13, 17, and 18 showed a remarkably broad spectrum of antimicrobial activity and could be useful as templates for further development through modification or derivatization to design more potent antimicrobial agents. A detailed synthesis of new 2-mercaptoquinazolinones and their antimicrobial screening are reported. Copyright © Taylor & Francis Group, LLC.