An efficient benzyltriethylammonium chloride catalysed preparation of electrophilic alkenes: A practical synthesis of trimethoprim

Abstract

The Knoevenagel condensation of carbonyl compounds with active methylene compounds was readily carried out with benzyltriethylammonium chloride as a catalytic agent, under solvent-free conditions to produce olefinic products in high yields: the scope of this protocol is utilised for the synthesis of the antibacterial agent trimethoprim.