Use of bumetanide in the treatment of ascites due to liver disease

Abstract

Bumetanide is an effective diuretic for the treatment of ascites. Fifteen out of 17 patients with chronic liver disease responded satisfactorily, and the incidence of hepatic encephalopathy and electrolyte disturbances was similar to that previously observed with frusemide. Colicky abdominal pain was reported in 3 patients, but no other adverse effects were noted. An unexpected response was obtained in 2 patiets who had diuresis without natriuresis.