Substituted N-methyl-N-nitrosoanilines are a novel class of protein S-nitrosation agents.

Abstract

Properly substituted N-alkyl-N-nitrosoanilines undergo S-transnitrosation with sulfhydryl-dependent enzymes under physiol. conditions. An electron-donating substitution at the para position of the Ph ring apparently assists the formation of the protonated reaction intermediate. The N-alkyl-N-nitrosoaniline structure can function as a stable, functional moiety in the design of NO releasing agents for biomedical and pharmaceutical applications. [on SciFinder (R)]