Occurrence and Dietary Intake of Organophosphate Esters via Animal-Origin Food Consumption in China: Results of a Chinese Total Diet Study

Abstract

Although diet is regarded as a major exposure source of organophosphate esters (OPEs), the dietary survey of OPEs in China has been limited. Based on the sixth Chinese Total Diet Study (TDS) conducted during 2016-2019 in 24 of 34 provinces in China, 14 OPEs were detected in 96 food composites from four animal-origin food categories. Twelve OPEs were detected in more than 80% of the samples and 2-ethylhexyl diphenyl phosphate (EHDPP) presented the highest median concentration (1.63 ng/g wet weight (ww)). The most contaminated food composite was meat, with a median Σ14OPEs of 13.6 ng/g ww, followed by aquatic food (11.5 ng/g ww), egg (7.63 ng/g ww), and milk (3.51 ng/g ww). The contribution of the meat group was close to or even greater than 50% in the estimated dietary intake (EDI) of OPEs. The average (range) EDI of the Σ14OPEs via animal food consumption for a Chinese "standard man"was 34.4 (6.18-73.3) ng/kg bodyweight (bw)/day. The geographical distribution showed higher EDI in southern coastal provinces compared to the northern inland provinces. Nevertheless, the highest EDI of Σ14OPEs from animal food was still more than 10 times lower than the reference dose. This is the first national survey of OPEs in foods from China.