Recognition of mixed-sequence DNA targets using spermine-modified Invader probes

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Abstract

Double-stranded oligodeoxyribonucleotides with +1 interstrand zipper arrangements of 2′-O-(pyren-1-yl)methyl-RNA monomers are additionally activated for highly specific recognition of mixed-sequence DNA targets upon incorporation of non-nucleotidic spermine bulges.

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Adhikari, S. P., Emehiser, R. G., Karmakar, S., & Hrdlicka, P. J. (2019). Recognition of mixed-sequence DNA targets using spermine-modified Invader probes. Organic and Biomolecular Chemistry, 17(39), 8795–8799. https://doi.org/10.1039/c9ob01686d

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