Macrophage's Arsenal in the Battle against Zaire EBOLA Virus

Abstract

Over forty years of extensive research has not yet solved the complexity of Ebola pathogenesis leading to a continued need for a successful cure. This virus has evolved different strategies to counteract immune responses as they are unreceptive to a large portion of the known antiviral drugs and there is no valid treatment as to date for disease created by this pathogen. A plethora of evidences have revealed that monocytes/macrophage contribute significantly in viral pathogenesis.