Interleukin-8 and laryngeal squamous cell carcinoma

Abstract

changes in the expression of cytokines and growth factors have implications in the malignant transformation of many cancers may be used as additional diagnostic markers in the sera of patients because of their excessive production by the tumor cells. This could be of great value since there are currently no reliable markers to predict either tumor development or relapse. Interleukin-8 (IL-8), a chemokine (C-X-C motif) ligand 8 (CXCL8), is now reported to play an important role in cancer invasion, angiogenesis and metastasis. Recent studies have shown an increased concentration of IL-8 in patients with LSCC and a positive association and cancer progression-free survival. The investigation of the mechanisms of origin, invasion, and metastasis of the cancer is could have a role as a screening test and as a support of the clinical decisions for appropriate therapy and postoperative care in individual patients. Biomed Rev 2018; 29: 47-55