Reaction of dimethyl N-(2,2-diethoxyethyl)-iminodithiocarbamate with primary amines: A new general approach for the synthesis of 1-substituted-2- methylthioimidazoles

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Abstract

Dimethyl N-(2,2-diethoxyethyl)-iminodithiocarbamate 3 is shown to react with primary amines in boiling acetic acid to afford 1-substituted-2- methylthioimidazoles in 81-87% overall yields.

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Sharma, S. K., Khan, T. A., Ila, H., & Junjappa, H. (2001). Reaction of dimethyl N-(2,2-diethoxyethyl)-iminodithiocarbamate with primary amines: A new general approach for the synthesis of 1-substituted-2- methylthioimidazoles. Arkivoc, 2001(8), 34–39. https://doi.org/10.3998/ark.5550190.0002.805

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