Chances and challenges in intranasal administration delivery for brain disease treatment

Abstract

In order to overcome the formidable challenges posed by the intricate physiological barriers of the brain, the employment of intranasal administration (INA) has emerged as an unconventional method for drug delivery, offering distinct advantages such as non-invasiveness and enhanced pharmacokinetic characteristics within the brain. Primarily exploiting the distinct conduit offered by the olfactory and/or trigeminal nerve systems, the INA route effectively delivers therapeutic agents. With introducing appropriate improvements to the drug formulation, such as the incorporation of nanocarriers, the efficacious delivery via the INA approach has gained considerable traction for the treatment of neurological disorders. This concise review highlights the notable progress in INA delivery and explores the potential therapeutic modalities inherent in this promising paradigm.