A Peptide Derived from IKK-Interacting Protein Attenuates NF-κB Activation and Inflammation

  • Liu H
  • Yan Z
  • Zhao Y
  • et al.
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Abstract

The IκB kinase (IKK) complex plays a vital role in regulating the NF-κB activation. Aberrant NF-κB activation is involved in various inflammatory diseases. Thus, targeting IKK activation is an ideal therapeutic strategy to cure and prevent inflammatory diseases related to NF-κB activation. In a previous study, we demonstrated that IKK-interacting protein (IKIP) inhibits the phosphorylation of IKKα/β and the activation of NF-κB through disruption of the formation of IKK complex. In this study, we identified a 15-aa peptide derived from mouse IKIP (46–60 aa of IKIP), which specifically suppressed IKK activation and NF-κB targeted gene expression via disrupting the association of IKKβ and NEMO. Importantly, administration of the peptide reduced LPS-induced acute inflammation and attenuated Zymosan-induced acute arthritis in mice. These findings suggest that this IKIP peptide may be a promising therapeutic reagent in the prevention and treatment of inflammatory diseases.

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APA

Liu, H., Yan, Z., Zhao, Y., Ma, X., Zhang, H., Wang, X., … Gao, C. (2021). A Peptide Derived from IKK-Interacting Protein Attenuates NF-κB Activation and Inflammation. The Journal of Immunology, 207(6), 1652–1661. https://doi.org/10.4049/jimmunol.2100397

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