Effects of green tea polyphenol on cognitive and acetylcholinesterase activities

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Abstract

The effect of tea polyphenol (TP) on cognitive and anti-cholinesterase activity was examined in scopolamine-treated mice. Chronic administration of TP significantly reversed scopolamine-induced retention deficits in both step-through passive avoidance and spontaneous alternation behavior tasks. Furthermore, TP exhibited a dramatic inhibitory effect on acetylcholinesterase activity. This finding suggests that TP might be useful in the treatment of Alzheimer's disease.

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Kim, H. K., Kim, M., Kim, S., Kim, M., & Chung, J. H. (2004). Effects of green tea polyphenol on cognitive and acetylcholinesterase activities. Bioscience, Biotechnology and Biochemistry, 68(9), 1977–1979. https://doi.org/10.1271/bbb.68.1977

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