A Novel Molecularly Imprinted Membrane for Highly Sensitive Electrochemical Detection of Paracetamol

Abstract

Molecularly imprinted polymers (MIPs) have been widely used for sensor fabrication. Paracetamol (PA) is a frequently prescribed antipyretic. With MIP and membrane separation technologies, a MIP was successfully synthesized in this study with PA being the template molecule. MIP was adopted to modify the electrodes in order to increase the sensitivity of the PA detection. The blotting, elution, and electrode regeneration mechanisms were also discussed and the adsorption of PA onto the electrode was investigated. The MIP-based electrochemical sensor can detect PA linearly from 1 pM to 0.1 mM with a detection limit of 3.6 pM under ideal conditions. In addition, the proposed sensor showed an excellent anti-interference performance.