Design of a sequence-specific DNA bisintercalator

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Abstract

Programmable bisintercalators: Symmetric synthetic DNA bisintercalators (see picture) based on the H-pin polyamide motif afford high affinity and programmable sequence specificity.

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Fechter, E. J., Olenyuk, B., & Dervan, P. B. (2004). Design of a sequence-specific DNA bisintercalator. Angewandte Chemie - International Edition, 43(27), 3591–3594. https://doi.org/10.1002/anie.200454231

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