Immunoglobulin G-4-Related Retroperitoneal Fibrosis

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Abstract

Retroperitoneal fibrosis is caused by the replacement of normal retroperitoneal tissue with fibrosis. The majority of the cases are idiopathic, but some secondary causes include malignancy, infection, drugs, and radiotherapy. Immunoglobulin G-4 (IgG-4) related disease is a relatively newer disease and one of the rarer causes of retroperitoneal fibrosis. It usually involves the pancreas, lungs, kidneys, aorta lacrimal and salivary glands, or extrapancreatic bile duct. Elevated serum IgG-4 is the biomarker of the disease and its levels correlate with disease activity. High-dose glucocorticoid is the treatment of choice.

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Huda, S. A., Kahlown, S. A., Elder, R., Kaul, V., & Landsberg, D. (2021). Immunoglobulin G-4-Related Retroperitoneal Fibrosis. Journal of Investigative Medicine High Impact Case Reports, 9. https://doi.org/10.1177/23247096211022487

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