One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor

Abstract

The scale-up of microwave-mediated reactions still poses a number of challenges but transfer from microwave batch reaction to continuous flow processing can offer many advantages for scale-up as demonstrated in the Bohlmann-Rahtz pyridine synthesis and the Hantzsch dihydropyridine synthesis using a conductive heating flow platform for the continuous processing of material. Part 1 of this two-part article describes the synthesis of pyridines. The synthesis of dihydropyridines will be described in the May/June 2014 issue of sp2 Inter-Active. © 2013, Bagley et al; licensee Beilstein-Institut.