Successful treatment of chronic hepatitis C with crushed tablet for sofosbuvir/ledipasvir

Abstract

A 65-year-old woman with early-onset Alzheimer’s disease and type 2 diabetes mellitus received a house call from a medical practitioner. Antiviral therapy could be performed for chronic hepatitis C (genotype 2), and she visited our hospital. It was difficult for her to take tablets because of early-onset Alzheimer’s disease; therefore, we provided crushed tablets of sofosbuvir/ledipasvir for 12 weeks. HCV-RNA in her blood showed negative conversion 8 weeks after treatment initiation, and SVR 12 was obtained. In antiviral therapy against chronic hepatitis C, it is necessary to carefully consider adaptation when treatment is indicated when the patient finds it difficult to take tablets. However, internal treatment with crushed tablets is believed to be an option. We report a case of antiviral treatment for chronic hepatitis C wherein it was difficult to take a tablet, and we experienced the case of a patient for whom treatment with crushed tablets was successful.