Biossíntese e funções das lipoxinas na resolução da inflamação.

Abstract

The resolution of infl ammation is an active endogenous process, in which lipoxins are important mediators. Lipoxins are mainly biosynthesized in the mucosa and blood vessels, and they and they activate a G-protein coupled receptor (FPR2/ALX) which is widely expressed in several cell types. Lipoxins have several pro-resolution actions, such as the reduction of the infi ltration of neutrophil in the infl ammatory site, the decrease in the production of superoxide and cytokines by granulocytes, the activation of phagocytosis of microorganisms and apoptotic cells by macrophages. In addition, lipoxins display direct antinociceptive effects.